論文紹介・執筆2019.01.08

■Publication list （発表論文、執筆書籍など）

(The following manuscripts #1, 2, 3 were for the Ph.D. thesis)

1. Hiromi Sakamoto, Takahiro Ochiya, Yumi Sato, Makoto Tsukamoto, Hiroyasu Konishi, Izumu Saito, Takashi Sugimura, and Masaaki Terada.Adenovirus-mediated transfer of the HST-1(FGF4) gene induces increased levels of platelet count in vivo.

Proceedings of the National Academy of Sciences of the U.S.A., 91: 12368-12372, 1994.

2. Hiroyasu Konishi, Takahiro Ochiya, Hiromi Sakamoto, Makoto Tsukamoto, Izumu Saito, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Effective prevention of thrombocytopenia in mice using adenovirus-mediated transfer of the HST-1(FGF-4) gene.
Journal of Clinical Investigation, 96: 1125-1130, 1995.

cf. Key Paper Reviews in Gene Therapy Newsletter

3. Hiroyasu Konishi, Takahiro Ochiya, Yuko Yasuda, Hiromi Sakamoto, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
HST-1/FGF-4 stimulates proliferation of megakaryocyte progenitors synergistically and promotes megakaryocyte maturtation.
Oncogene, 13: 9-19, 1996.

4.Hiroyasu Konishi, Takahiro Ochiya, Hiromi Sakamoto, Makoto Tsukamoto, Yuko Yasuda, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Effective prevention of thrombocytopenia using adenovirus-mediated transfer of the HST-1(FGF-4) gene: in vivo and in vitro studies.
Leukemia, 11, Suppl.3: 530-532, 1997.

5. Hiroyasu Konishi, Takahiro Ochiya, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Toward targeted killing of tumor-specific antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Cancer Gene Therapy, 4: 323-324, 1997.

6. Hiroyasu Konishi, Takahiro Ochiya, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Targeted killing of CEA-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Tumor Biology, 18, Suppl. 2: 60, 1997.

7. 小西宏育、寺田雅昭： FGFRファミリー（review）.
Bio Science 用語ライブラリー　癌遺伝子・癌抑制遺伝子.
田矢洋一、山本雅編、羊土社、177-179（1997）.

8. Hiroyasu Konishi, Takahiro Ochiya, Kerry A. Chester, Richard H. J. Begent, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Human Gene Therapy, 9: 235-248, 1998.

9. Hiroyasu Konishi, Takahiro Ochiya, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Toward targeted killing of tumor- specific antigen- producing cancer cells by retrovirus displaying a single chain variable fragment antibody.
Adv. Exp. Med. Biol., 451: 405- 410, 1998

10. Yasushi Takahama, Takahiro Ochiya, Hiroki Sasaki, Hiroyau Toriyama-Baba, Hiroyasu Konishi, Hiroshi Nakano, Masaaki Terada.
Molecular cloning and functional analysis of cDNA encoding a rat leukemia inhibitory factor: towards generation of pluripotent rat embryonic stem cells.
Oncogene, 24: 3189-3196, 1998.

11. Hiroyasu Konishi, Takahiro Ochiya, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Toward targeted killing of tumor-specific antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Gene Therapy of Cancer (P. Walden, U. Trefzer, W. Sterry, and F. Farzaaneh, eds.), Plenum Press Co., New York, NY, U.S.A., 405.

12. 小西宏育、武藤徹一郎： 大腸癌に特異的な標的遺伝子治療法の開発. 日本外科系連合学会誌, 24, 1（1999）.

13. 小西宏育：固形癌～大腸癌. 遺伝子治療開発研究ハンドブック. 日本遺伝子治療学会編, エヌ・ティー・エス., 東京, 164（1999）.

14. Jun Yamakoshi, Shoich Tokutake, Mamoru Kikuchi, Yoshiro Kubota, Hiroyasu Konishi, and Tomotari Mitsuoka.
Effect of Proanthocyanidin-rich extract from grape seeds on human fecal flora and fecal odor.
Microbial Ecology in Health and Disease. 13: 25-31, 2001.

■Oral Presentation in English （英語での口演発表）

1. Hiroyasu Konishi, Takahiro Ochiya, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Targeted Killing of Carcinoembryonic Antigen-Producing Cancer Cells by Retrovirus Displaying a Single Chain Variable Fragment Antibody.
Vector Targeting Strategies for Therapeutic Gene Delivery, Biotechnology Conference, Cold Spring Harbor Laboratory, New York, USA、Abstracts p17、March 15, 1997

2. Hiroyasu Konishi, Takahiro Ochiya, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Toward targeted killing of tumor-specific antigen-producing cancer cells by retrovirus displaying a single chain variable fragment antibody.
The 3rd European conference on gene therapy of cancer, Berlin,Germany, abstracts p107, September 12, 1997 workshop

3. Hiroyasu Konishi, Takahiro Ochiya, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Targeted killing of CEA-producing cancer cells by retrovirus displaying a single chain variable fragment antibody.
The XXVth Anniversary Meeting of the International Society for Oncodevelopmental Biology and Medicine, Montreux, Switzerland, abstracts p60 September 22, 1997 workshop.

4. Hiroyasu Konishi.
Targeting strategies for gene therapy of CEA-producing cancer
Monthly seminar of National Cancer Center Research Institute.　November 17, 1997.

5. Hiroyasu Konishi, Takahiro Ochiya, Tetsuichiro Muto, Takashi Sugimura, and Masaaki Terada.
Two Targeting Strategies for Gene Therapy of CEA-Producing Cancer.Molecular and Cellular Biology of Gene Therapy, Keystone Symposium, Keystone, Colollado, USA. January 19. 1998.

6. Hiroyasu Konishi.
Targeting strategies for gene therapy of CEA-producing cancer.
Invited Seminar at University of Alabama at Birmingham, USA
January 26, 1998.

■その他.

1997年5月12日付けの日本経済新聞朝刊の科学面に、研究内容が、所属、氏名と共に、癌の標的遺伝子治療の見出しで紹介掲載されました。